Description

L-Proline, 5-(1-Methylethyl)-, cis- (9Ci) is a specialized, non-proteinogenic proline derivative characterized by its unique isopropyl substitution on the pyrrolidine ring. This compound matters as a valuable chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel pharmaceuticals and bioactive molecules. It is needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for applications in asymmetric synthesis, peptide mimetics, and medicinal chemistry research.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for protease inhibitors and other targeted therapies.
• Peptidomimetics & Drug Design: Used to introduce conformational constraints and enhance metabolic stability in the design of peptide-based drugs and mimetics.
• Asymmetric Catalysis: Acts as a precursor for chiral ligands or organocatalysts used in stereoselective synthesis.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, or plant growth regulators with specific stereochemical requirements.
• Biochemical Research: Utilized as a probe or substrate in enzymatic studies to investigate substrate specificity and enzyme mechanisms.
• Fine Chemical Synthesis: Functions as a specialized intermediate for the production of complex, high-value organic compounds.

Basic Information

Product Name	L-Proline, 5-(1-Methylethyl)-, cis- (9Ci)
CAS No.	110452-55-6
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	cis-5-Isopropyl-L-proline; (2S,5S)-5-Isopropylproline; L-Proline, 5-(1-methylethyl)-, (2S,5S)-; cis-5-(1-Methylethyl)-L-proline; (2S,5S)-5-(1-Methylethyl)proline; 5-Isopropyl-L-proline (cis); (S,S)-5-Isopropylproline
EINECS	Contact for details

Quality Control

Our L-Proline, 5-(1-Methylethyl)-, cis- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as chiral purity, enantiomeric excess, and related substances are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.