Description

3-Isoxazolamine,5-(Trifluoromethyl)-(9Ci) is a specialized heterocyclic building block featuring a reactive amino group on the isoxazole ring. This compound matters for its role as a key synthetic intermediate in the development of advanced agrochemicals and pharmaceuticals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development teams in the fine chemical, pharmaceutical, and crop protection industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a core scaffold in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective research.
• Agrochemical Synthesis: Used as a key building block for developing new herbicides, fungicides, and insecticides, leveraging the bioactivity of the isoxazole ring.
• Material Science Research: Employed in the creation of specialty polymers and functional materials that require fluorinated heterocyclic components.
• Chemical Biology: Acts as a probe or linker in medicinal chemistry for structure-activity relationship (SAR) studies and target identification.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	3-Isoxazolamine,5-(Trifluoromethyl)-(9Ci)
CAS No.	110234-43-0
Molecular Formula	C4H3F3N2O
Molecular Weight	152.08 g/mol
Synonyms	5-(Trifluoromethyl)-1,2-oxazol-3-amine; 5-(Trifluoromethyl)-3-isoxazolamine; 3-Amino-5-(trifluoromethyl)isoxazole; 5-(Trifluoromethyl)isoxazol-3-amine; 3-Isoxazolamine, 5-(trifluoromethyl)-; 110234-43-0; 5-Trifluoromethyl-3-isoxazolamine
EINECS	Contact for details

Quality Control

Our 3-Isoxazolamine,5-(Trifluoromethyl)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.