Description

1-Fluoro-2-Iodo-4-(Trifluoromethyl)Benzene is a versatile halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring fluorine, iodine, and a trifluoromethyl group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorine and iodine atoms which can modulate bioavailability, metabolic stability, and receptor binding.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorine-containing aromatic cores in advanced electronic materials, contributing to improved charge transport, thermal stability, and optical properties.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Stille) to create complex biaryl and conjugated systems.
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and for the development of new fluorination methodologies and fluorinated compound libraries.
• Ligand & Catalyst Development: Utilized in the synthesis of specialized ligands for catalysis, where the electron-withdrawing groups can fine-tune metal center reactivity.

Basic Information

Item	Detail
Product Name	1-Fluoro-2-Iodo-4-(Trifluoromethyl)Benzene
CAS No.	110192-48-8
Molecular Formula	C7H3F4I
Molecular Weight	305.99 g/mol
Synonyms	2-Fluoro-1-Iodo-4-(Trifluoromethyl)Benzene; 4-(Trifluoromethyl)-1-fluoro-2-iodobenzene; 1-Fluoro-2-iodo-α,α,α-trifluorotoluene; 2-Iodo-α,α,α-trifluoro-4-fluorotoluene; 4-Fluoro-3-iodobenzotrifluoride; 3-Iodo-4-fluorobenzotrifluoride; Benzene, 1-fluoro-2-iodo-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1-Fluoro-2-Iodo-4-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and mass spectrometry to verify identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring full traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.