Description

α-Monofluoromethyl-3,4-Dehydroarginine is a specialized, non-proteinogenic amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and a potent mechanism-based inhibitor for enzymes involved in nitric oxide biosynthesis and polyamine metabolism. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel therapeutics for cardiovascular diseases, neurological disorders, and cancer. The high-purity material is essential for ensuring reproducible and reliable experimental and pre-clinical results.

Application

• Pharmaceutical Research: Key intermediate and active pharmacophore in the synthesis of novel enzyme inhibitors targeting nitric oxide synthase (NOS) isoforms.
• Biochemical Tool Compound: Used as a potent, irreversible inhibitor in enzymatic studies to investigate arginine metabolism pathways and polyamine synthesis.
• Pre-clinical Drug Development: Serves as a lead compound or a critical starting material for developing potential therapeutics for conditions like sepsis, stroke, and neurodegenerative diseases.
• Academic Research: Employed in university and institutional labs for fundamental studies on cell signaling, apoptosis, and vascular biology.
• Proteomics & Chemical Biology: Utilized in activity-based protein profiling (ABPP) to identify and characterize enzyme families in complex biological systems.

Basic Information

Product Name	α-Monofluoromethyl-3,4-Dehydroarginine
CAS No.	109857-48-9
Molecular Formula	C7H12FN3O2
Molecular Weight	189.19 g/mol
Synonyms	L-α-(Fluoromethyl)dehydroarginine; (S)-2-Amino-5-[(aminoiminomethyl)amino]-2-fluoro-2-pentenoic Acid; 2-Fluoromethyl-δ-2-arginine; FMDA; Nω-Amino-α-fluoromethylarginine; α-Fluoromethyldehydroarginine; L-α-(Fluoromethyl)dehydroarginine; NO synthase inhibitor
EINECS	Contact for details

Quality Control

Every batch of α-Monofluoromethyl-3,4-Dehydroarginine is produced and analyzed under strict quality management protocols to ensure the highest standards of purity and consistency required for research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with stringent in-house specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.