Description

(R)-1-Aminohexylphosphonic Acid is a chiral, non-proteinogenic amino acid analog featuring a phosphonic acid group, which serves as a stable bioisostere for the phosphate group. This structural characteristic makes it a valuable intermediate in the design and synthesis of enzyme inhibitors, particularly for metalloenzymes, and as a building block for novel bioactive compounds. It is primarily sought by researchers and manufacturers in the pharmaceutical and agrochemical industries for applications in drug discovery, medicinal chemistry, and the development of specialized catalysts.

Application

• Key chiral intermediate in the synthesis of pharmaceutical active ingredients (APIs), especially those targeting bone metabolism or enzymatic pathways.
• Building block for metal-chelating ligands used in catalysis and material science.
• Precursor for the development of novel phosphonate-based prodrugs and diagnostic agents.
• Research chemical in medicinal chemistry for structure-activity relationship (SAR) studies of amino acid analogs.
• Component in the synthesis of specialized agrochemicals, such as herbicides or plant growth regulators with chiral specificity.
• Starting material for creating custom peptides and peptidomimetics with enhanced metabolic stability.

Basic Information

Product Name	(R)-1-Aminohexylphosphonic Acid
CAS No.	109638-78-0
Molecular Formula	C₆H₁₆NO₃P
Molecular Weight	181.17 g/mol
Synonyms	(R)-1-Aminohexylphosphonic Acid; (R)-6-Aminohexylphosphonic Acid; (R)-6-Amino-1-hexanephosphonic Acid; D-1-Aminohexylphosphonic Acid; (R)-Aminohexylphosphonate; (R)-AHPA; Phosphonic acid, P-[(1R)-1-aminohexyl]-; (R)-1-Amino-hexyl-phosphonsaeure
EINECS	Contact for details

Quality Control

Our (R)-1-Aminohexylphosphonic Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing specific results for chiral purity, chemical purity, and residual solvents are provided with every shipment to support your research and development or cGMP manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Loss on Drying	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.