Description

5-Fluoroarachidonic Acid is a fluorinated analog of the essential fatty acid arachidonic acid, distinguished by the substitution of a fluorine atom at the 5-position. This structural modification makes it a critical biochemical tool for studying lipid signaling pathways, particularly those involving cyclooxygenase (COX) and lipoxygenase (LOX) enzymes. It is primarily utilized by researchers and developers in pharmaceutical R&D, biochemical research, and metabolic studies to investigate inflammation, eicosanoid biology, and to develop novel enzyme inhibitors.

Application

• Biochemical Research: A key probe for investigating the metabolism and biological activity of fluorinated eicosanoids.
• Enzyme Inhibition Studies: Used as a substrate analog to study the mechanism and inhibition of cyclooxygenase (COX-1/COX-2) and lipoxygenase enzymes.
• Pharmaceutical Development: Serves as a valuable intermediate or reference standard in the discovery of novel anti-inflammatory and analgesic agents.
• Metabolic Pathway Analysis: Employed in tracer studies to elucidate the metabolic fate of modified polyunsaturated fatty acids in cellular systems.
• Lipidomics: Used as a standard compound in mass spectrometry-based lipid profiling and identification.
• Academic Research: Fundamental tool for universities and research institutes studying lipid biochemistry, signal transduction, and drug mechanisms.

Basic Information

Product Name	5-Fluoroarachidonic Acid
CAS No.	109522-28-3
Molecular Formula	C₂₀H₃₁FO₂
Molecular Weight	322.46 g/mol
Synonyms	(5Z,8Z,11Z,14Z)-5-Fluoroicosa-5,8,11,14-tetraenoic Acid; FAArA; 5-Fluoro-5Z,8Z,11Z,14Z-eicosatetraenoic Acid; 5-Fluoro-AA; 5-F-AA; 5-Fluoroarachidonate; 5-Fluoroeicosa-5,8,11,14-tetraenoic Acid
EINECS	Contact for details

Quality Control

Our 5-Fluoroarachidonic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.