Description

Cyclohexanecarboxaldehyde, 4-Hydroxy-3-Methoxy-, [1R-(1Alpha,3Alpha,4Beta)]- (9Ci) is a high-purity, stereochemically defined chiral aldehyde derivative of vanillin. This compound matters as a sophisticated building block and intermediate for the synthesis of complex molecules, offering precise stereochemical control. It is primarily needed by research and development teams in the pharmaceutical and fine chemical industries for creating novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Asymmetric Synthesis: Serves as a versatile chiral aldehyde component in stereoselective reactions, including aldol condensations and reductive aminations.
• Fragrance & Flavor Chemistry: Used in the research and development of advanced, structurally complex aroma chemicals derived from vanillin.
• Ligand & Catalyst Development: Acts as a starting material for synthesizing chiral ligands used in homogeneous catalysis.
• Agrochemical Research: Employed in creating novel, stereospecific active ingredients for crop protection.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and process development.

Basic Information

Product Name	Cyclohexanecarboxaldehyde, 4-Hydroxy-3-Methoxy-, [1R-(1Alpha,3Alpha,4Beta)]- (9Ci)
CAS No.	109466-72-0
Molecular Formula	C9H14O3
Molecular Weight	170.21 g/mol
Synonyms	(1R,3R,4S)-4-Hydroxy-3-methoxycyclohexanecarboxaldehyde; (1R,3R,4S)-3-Methoxy-4-hydroxycyclohexanecarbaldehyde; Vanillin-derived chiral cyclohexanecarboxaldehyde; (1R,3R,4S)-4-Hydroxy-3-methoxy-1-cyclohexanecarboxaldehyde; Chiral Cyclohexyl Vanillin Aldehyde
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high stereochemical purity. Quality is verified through advanced analytical techniques including chiral HPLC, NMR, and GC. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). For long-term storage, consider storage under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.