Description

2,4-Di(tert-Butoxy)Pyrimidin-5-Ylboronic Acid Hydrate is a high-purity, functionalized pyrimidine boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its primary value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials development. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and kinase inhibitor drugs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators containing pyrimidine motifs.
• Material Science: Building block for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and enzyme inhibitors for target identification and validation.
• Library Synthesis for Drug Discovery: Facilitates the rapid construction of diverse compound libraries for high-throughput screening in medicinal chemistry.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing novel ligands and organometallic catalysts used in asymmetric synthesis.

Basic Information

Product Name	2,4-Di(tert-Butoxy)Pyrimidin-5-Ylboronic Acid Hydrate
CAS No.	109299-79-8
Molecular Formula	C₁₂H₂₁BN₂O₄ • xH₂O
Molecular Weight	268.12 g/mol (anhydrous basis)
Synonyms	5-Borono-2,4-di-tert-butoxypyrimidine Hydrate; 2,4-Bis(tert-butoxy)-5-pyrimidineboronic Acid Hydrate; (2,4-Di-tert-butoxypyrimidin-5-yl)boronic Acid Hydrate; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,4-di-tert-butoxypyrimidine (protected form); DTBPBA Hydrate; Pyrimidine-5-boronic Acid, 2,4-di-tert-butoxy-, Hydrate
EINECS	Contact for details

Quality Control

Our 2,4-Di(tert-Butoxy)Pyrimidin-5-Ylboronic Acid Hydrate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and consistent performance in cross-coupling reactions. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.