Description

Phenol, 4-(1,3,2-Dioxaborolan-2-Yl)- (9Ci) is a versatile organoboron compound, specifically a phenol derivative bearing a cyclic boronic ester protecting group. This structure is critical for its role as a key synthetic intermediate in modern organic and medicinal chemistry, enabling precise cross-coupling reactions. It is primarily sought after by research institutions and pharmaceutical companies for the development of new active pharmaceutical ingredients (APIs) and advanced materials. Its utility stems from the protected boronic acid functionality, which offers enhanced stability and reactivity control compared to its free acid form.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A fundamental building block for creating biaryl and heterobiaryl structures, which are core scaffolds in numerous pharmaceuticals and agrochemicals.
• Pharmaceutical Intermediate: Used in the synthesis of complex drug candidates, particularly in oncology, CNS, and anti-inflammatory research pipelines.
• Material Science Research: Serves as a monomer or precursor for developing novel polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the synthesis of probes and inhibitors that target enzymes or biological pathways, leveraging the phenol and boronate functionalities.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides, fungicides, and plant growth regulators with improved efficacy.
• Academic & Process Chemistry: A valuable reagent for methodological development and scaling up synthetic routes in both academic and industrial R&D settings.

Basic Information

Item	Detail
Product Name	Phenol, 4-(1,3,2-Dioxaborolan-2-Yl)- (9Ci)
CAS No.	108305-41-5
Molecular Formula	C9H11BO3
Molecular Weight	177.99 g/mol
Synonyms	4-(1,3,2-Dioxaborolan-2-yl)phenol; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (common mis-assignment, verify structure); 2-(4-Hydroxyphenyl)-1,3,2-dioxaborolane; 4-Hydroxyphenylboronic acid 1,3-propanediol ester; 4-Hydroxyphenylboronic acid cyclic ester; Phenol, p-(1,3,2-dioxaborolan-2-yl)-; B-(4-Hydroxyphenyl)-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Every batch of Phenol, 4-(1,3,2-Dioxaborolan-2-Yl)- (9Ci) is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for high-purity research chemicals. Comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom purity grades can be discussed to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.