Description

10,10-Difluoroarachidonic Acid is a fluorinated derivative of arachidonic acid, a key polyunsaturated fatty acid. This chemical modification introduces fluorine atoms at a specific position, creating a valuable biochemical tool for studying lipid metabolism and eicosanoid signaling pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for drug discovery and metabolic research.

Application

• Biochemical Research: Acts as a stable analog and metabolic probe for studying arachidonic acid pathways, including cyclooxygenase (COX) and lipoxygenase (LOX) enzyme activities.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the discovery and synthesis of novel anti-inflammatory and analgesic drug candidates.
• Metabolomics Studies: Used as an internal standard or tracer in mass spectrometry-based lipidomics to quantify eicosanoids and related metabolites.
• Enzyme Inhibition Studies: Employed to investigate the mechanism of action and potency of inhibitors targeting enzymes in the eicosanoid biosynthesis cascade.
• Cell Signaling Research: Applied in cell culture models to modulate prostaglandin, leukotriene, and thromboxane production for functional assays.

Basic Information

Product Name	10,10-Difluoroarachidonic Acid
CAS No.	108212-58-4
Molecular Formula	C20H30F2O2
Molecular Weight	332.45 g/mol
Synonyms	10,10-Difluoro-5Z,8Z,11Z,14Z-eicosatetraenoic Acid; (5Z,8Z,11Z,14Z)-10,10-Difluoroicosa-5,8,11,14-tetraenoic Acid; Difluoroarachidonic Acid; 10,10-Difluoro-AA; 10,10-Difluoroarachidonate; DFAA
EINECS	Contact for details

Quality Control

Our 10,10-Difluoroarachidonic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). The product is moisture-sensitive and should be handled in a dry environment to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95% (Area %)
Assay (NMR)	≥ 90%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in ethanol, DMSO, and common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.