Description

(R)-4,4,4-Trifluoro-3-Hydroxybutyric Acid CAS NO 108211-36-5 is a high-value, chiral trifluoromethylated building block essential for the synthesis of advanced pharmaceuticals and agrochemicals. Its core value lies in the unique combination of a stereogenic center and a trifluoromethyl group, which is critical for modulating the biological activity, metabolic stability, and lipophilicity of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical industry for creating novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas like metabolic diseases and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel APIs, especially those targeting metabolic pathways.
• Agrochemical Research: Used in developing advanced herbicides and pesticides where the trifluoromethyl group enhances activity and environmental stability.
• Fluorinated Amino Acid Analogue: Serves as a precursor for non-natural, fluorinated amino acids used in peptide-based drug discovery.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Material Science: Potential monomer or modifier for creating specialty polymers with unique surface properties.
• Diagnostic Agent Synthesis: Used in the development of fluorinated probes and contrast agents for medical imaging.

Basic Information

Product Name	(R)-4,4,4-Trifluoro-3-Hydroxybutyric Acid
CAS No.	108211-36-5
Molecular Formula	C4H5F3O3
Molecular Weight	158.08 g/mol
Synonyms	(R)-3-Hydroxy-4,4,4-trifluorobutanoic Acid; (R)-4,4,4-Trifluoro-3-hydroxybutanoic Acid; (R)-TFBA; (3R)-4,4,4-Trifluoro-3-hydroxybutyric Acid; (R)-HOTfBA; (R)-Trifluorohydroxybutyric Acid; (R)-3-Hydroxy-4,4,4-trifluorobutyric Acid; (R)-γ-Trifluoro-β-hydroxybutyric Acid
EINECS	Contact for details

Quality Control

Our (R)-4,4,4-Trifluoro-3-Hydroxybutyric Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with high-purity standards for research and development use. Certificates of Analysis (COA) detailing purity, identity, and chiral purity are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.