Description

4-(Trifluoromethoxy)-2,2,2-Trifluoroacetophenone is a high-value, multi-fluorinated aromatic ketone building block essential for advanced organic synthesis. Its unique trifluoromethoxy and trifluoroacetyl functional groups make it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily sought after by R&D and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting the central nervous system, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to improve chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: A versatile reagent in cross-coupling reactions, Friedel-Crafts acylations, and as a precursor for heterocyclic compounds containing trifluoromethyl groups.

Basic Information

Product Name	4-(Trifluoromethoxy)-2,2,2-Trifluoroacetophenone
CAS No.	107713-64-4
Molecular Formula	C9H4F6O2
Molecular Weight	258.12 g/mol
Synonyms	1-[4-(Trifluoromethoxy)phenyl]-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-[4-(trifluoromethoxy)phenyl]ethanone; 4-(Trifluoromethoxy)phenyl trifluoromethyl ketone; α,α,α-Trifluoro-4'-(trifluoromethoxy)acetophenone; p-(Trifluoromethoxy)trifluoroacetophenone; TFMO-TFA; 4-TFMO-α,α,α-TFA
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethoxy)-2,2,2-Trifluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.