Description

Methyl 3-Amino-4,4,4-Trifluorocrotonate is a versatile fluorinated building block characterized by a reactive amino and ester functional group on a trifluoromethyl-substituted alkene. This compound matters for its unique structure, which enables the synthesis of complex molecules with enhanced properties like metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of fluorinated heterocycles, such as pyrazoles and pyrimidines, which are core structures in many drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides and insecticides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent for synthesizing specialty polymers with unique surface properties or refractive indices.
• Fluorine Chemistry Research: An essential reagent for studying nucleophilic addition and cyclization reactions involving fluorinated enamines and enol esters.
• Ligand and Catalyst Development: Utilized to prepare chelating agents or organocatalysts that incorporate fluorine for tuning electronic properties and selectivity.

Basic Information

Product Name	Methyl 3-Amino-4,4,4-Trifluorocrotonate
CAS No.	107638-19-7
Molecular Formula	C5H6F3NO2
Molecular Weight	169.10 g/mol
Synonyms	Methyl 3-Amino-4,4,4-Trifluorobut-2-Enoate; 3-Amino-4,4,4-Trifluorocrotonic Acid Methyl Ester; 4,4,4-Trifluoro-3-aminocrotonic Acid Methyl Ester; Methyl (Z)-3-Amino-4,4,4-Trifluorocrotonate; (Z)-Methyl 3-Amino-4,4,4-Trifluorobut-2-Enoate; 3-Amino-4,4,4-Trifluoro-2-Butenoic Acid Methyl Ester; 2-Butenoic Acid, 3-Amino-4,4,4-Trifluoro-, Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl 3-Amino-4,4,4-Trifluorocrotonate is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.