Description

3,3-Difluorocyclobutanecarboxylic Acid is a high-value fluorinated building block characterized by its strained cyclobutane ring and carboxylic acid functionality. This compound is essential for medicinal chemistry research and development, enabling the precise modulation of a molecule's physicochemical and metabolic properties. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the design and synthesis of novel drug candidates, particularly for introducing fluorine atoms to improve metabolic stability, bioavailability, and membrane permeability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the difluorocyclobutyl moiety can enhance biological activity and environmental profile.
• Material Science Precursor: Serves as a monomer or building block for specialty polymers and advanced materials with unique thermal and chemical resistance properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands and catalysts for asymmetric synthesis and other catalytic processes.
• Fluorine-Containing Compound Library: A critical starting material for combinatorial chemistry and the generation of diverse fluorinated compound libraries for high-throughput screening.
• PET (Positron Emission Tomography) Tracer Precursor: Potential use in the synthesis of fluorine-18 labeled radiopharmaceuticals for diagnostic imaging.

Basic Information

Product Name	3,3-Difluorocyclobutanecarboxylic Acid
CAS No.	107496-54-8
Molecular Formula	C5H6F2O2
Molecular Weight	136.10 g/mol
Synonyms	3,3-Difluorocyclobutane-1-carboxylic Acid; Cyclobutanecarboxylic acid, 3,3-difluoro-; 3,3-Difluorocyclobutanecarboxylate; 1-Carboxy-3,3-difluorocyclobutane; 3,3-Difluorocyclobutylcarboxylic Acid; 3,3-Difluorocyclobutanecarboxylic acid (CAS 107496-54-8); 3,3-Difluorocyclobutanecarboxylic acid, 95%+; 3,3-Difluorocyclobutanecarboxylic acid, 98%+
EINECS	Contact for details

Quality Control

Our 3,3-Difluorocyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.