Description

2,3,5,6-Tetrafluorobenzyl Chloride is a versatile fluorinated benzyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in introducing the reactive chloromethyl group onto a highly fluorinated aromatic core, enabling the creation of complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors, where precise fluorination is required to modulate bioactivity, stability, and physical characteristics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a tetrafluorobenzyl moiety to enhance metabolic stability or binding affinity.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorinated aromatic structure contributes to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer & Resin Modification: Employed to introduce fluorinated benzyl groups into polymer chains, enhancing chemical resistance, surface properties, and durability of specialty coatings and resins.
• Cross-coupling Reagent: Acts as an electrophile in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex biaryl systems.
• Ligand & Catalyst Preparation: Useful for synthesizing fluorinated ligands for metal complexes used in homogeneous catalysis.

Basic Information

Product Name	2,3,5,6-Tetrafluorobenzyl Chloride
CAS No.	107267-44-7
Molecular Formula	C7H3ClF4
Molecular Weight	198.55 g/mol
Synonyms	2,3,5,6-Tetrafluorobenzyl Chloride; (2,3,5,6-Tetrafluorophenyl)methyl Chloride; α-Chloro-2,3,5,6-tetrafluorotoluene; 2,3,5,6-Tetrafluoro-α-chlorotoluene; 1-(Chloromethyl)-2,3,5,6-tetrafluorobenzene; Benzene, 1-(chloromethyl)-2,3,5,6-tetrafluoro-; Perfluorobenzyl Chloride (common name for tetrafluoro derivative)
EINECS	Contact for details

Quality Control

Our 2,3,5,6-Tetrafluorobenzyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.