Description

Ethyl 2-Hydroxy-2-(Trifluoromethyl)Propanoate is a versatile fluorinated building block characterized by its hydroxy and ester functionalities. This compound is valued for its ability to introduce the highly stable trifluoromethyl group into more complex molecular architectures, significantly altering physical and chemical properties. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring the metabolic stability and lipophilicity conferred by the trifluoromethyl group.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the CF3 moiety enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or modifying agent in the synthesis of specialty polymers and coatings with unique surface properties, such as oil and water repellency.
• Liquid Crystal & Electronic Chemicals: Employed in the synthesis of fluorinated components for liquid crystal displays (LCDs) and other electronic materials.
• Organic Synthesis Building Block: Utilized in academic and industrial R&D for constructing complex fluorinated molecules via reactions at the hydroxy or ester functional groups.

Basic Information

Product Name	Ethyl 2-Hydroxy-2-(Trifluoromethyl)Propanoate
CAS No.	107018-39-3
Molecular Formula	C6H9F3O3
Molecular Weight	186.13 g/mol
Synonyms	2-Hydroxy-2-(trifluoromethyl)propanoic acid ethyl ester; Ethyl 2-hydroxy-2-(trifluoromethyl)propionate; Ethyl 3,3,3-trifluoro-2-hydroxy-2-methylpropionate; 2-(Trifluoromethyl)lactic acid ethyl ester; α-Hydroxy-α-(trifluoromethyl)propionic acid ethyl ester; TFML Ethyl Ester; Ethyl α-hydroxy-α-trifluoromethylpropionate
EINECS	Contact for details

Quality Control

Our Ethyl 2-Hydroxy-2-(Trifluoromethyl)Propanoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC/GC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider using an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.