Description

(R)-2-Phenyloxetane CAS NO 106760-61-6 is a high-value, chiral oxetane building block of significant interest in modern organic synthesis and pharmaceutical research. Its rigid, strained oxetane ring serves as a versatile bioisostere, offering a strategic advantage in drug design for modulating the physicochemical and metabolic properties of lead compounds. This enantiomerically pure intermediate is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the oxetane moiety can enhance stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer and Material Science: Incorporated into specialty polymers to modify thermal properties, rigidity, and solubility for high-performance applications.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological systems and target engagement.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of chiral molecules.

Basic Information

Product Name	(R)-2-Phenyloxetane
CAS No.	106760-61-6
Molecular Formula	C9H10O
Molecular Weight	134.18 g/mol
Synonyms	(R)-2-Phenyloxacyclobutane; (R)-2-Phenyl-1-oxacyclobutane; (R)-2-Phenyloxetane; (R)-Oxetane, 2-phenyl-; (2R)-2-Phenyloxetane; (R)-2-Phenyl-oxetane; (R)-2-Phenyloxetan; (R)-2-Phenyl-oxacyclobutane
EINECS	Contact for details

Quality Control

Every batch of (R)-2-Phenyloxetane is manufactured and analyzed under strict quality management protocols to ensure high enantiomeric purity and chemical consistency, meeting the exacting standards of research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing chiral purity, chemical purity, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.