Description

Viriplanin A is a structurally complex glycolipopeptide antibiotic originally isolated from Planobispora rosea, recognized for its potent activity against Gram-positive bacteria—including multidrug-resistant strains such as vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). It functions by inhibiting bacterial cell wall biosynthesis through a unique mechanism distinct from glycopeptides like vancomycin, making it a high-value candidate for anti-infective drug discovery and preclinical development. Researchers and pharmaceutical developers engaged in novel antibiotic screening, structure–activity relationship (SAR) studies, and lead optimization rely on high-purity Viriplanin A CAS NO 106153-36-0 for reproducible biological assays and mechanistic investigations.

Application

• Preclinical antimicrobial research targeting drug-resistant Gram-positive pathogens
• Lead compound in the development of next-generation antibiotics with novel modes of action
• Biochemical tool for studying peptidoglycan biosynthesis and cell wall assembly inhibition
• Reference standard in HPLC and LC-MS/MS method development and validation
• Structural scaffold for semi-synthetic derivatization to improve pharmacokinetic properties
• In vitro target engagement and resistance profiling studies
• Comparative efficacy assessment against other glycopeptide and lipopeptide antibiotics
• Quality control reference material for biosynthetic production batches

Basic Information

Product Name	Viriplanin A
CAS No.	106153-36-0
Molecular Formula	C74H114N12O24
Molecular Weight	1559.78 g/mol
Synonyms	Viriplanin A; Viriplanin; Planobisporin A; RP 71955; RP-71955; Antibiotic RP-71955; (3S,6S,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S)-3-(2-Amino-3-methylbutanoyl)-6-(2-amino-3-methylbutanoyl)-9-(2-amino-3-methylbutanoyl)-12-(2-amino-3-methylbutanoyl)-15-(2-amino-3-methylbutanoyl)-18-(2-amino-3-methylbutanoyl)-21-(2-amino-3-methylbutanoyl)-24-(2-amino-3-methylbutanoyl)-27-(2-amino-3-methylbutanoyl)-30-(2-amino-3-methylbutanoyl)-33-(2-amino-3-methylbutanoyl)-36-(2-amino-3-methylbutanoyl)-1,4,7,10,13,16,19,22,25,28,31,34-dodecaazacyclotetratriacontane-37,38-dione
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches of Viriplanin A are tested for identity (HPLC retention time match, IR spectral overlay), assay (HPLC area normalization), related substances (HPLC gradient method), residual solvents (GC), and heavy metals (USP <231>). Testing adheres to ICH Q5, Q6A, and Q7 guidelines for biologically derived active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C under inert atmosphere (argon or nitrogen) to prevent degradation. Keep desiccated; avoid exposure to ambient humidity due to hygroscopic nature. Handle under low-light conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time matches reference standard (±0.2 min)
Identification (IR)	Characteristic peaks consistent with reference spectrum
Assay (HPLC)	≥ 95.0%
Related Substances	≤ 3.0% total impurities
Single Impurity	≤ 0.5%
Residual Solvents (Acetonitrile, Methanol)	Complies with ICH Q3C Class 3 limits
Water (Karl Fischer)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.