Description

L-Aspartic Acid, 3-Fluoro-, Threo- (9Ci) is a fluorinated derivative of the essential amino acid L-aspartic acid, characterized by the introduction of a fluorine atom at the 3-position in the threo configuration. This specific structural modification makes it a valuable chiral building block and intermediate for advanced pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the life sciences sector. The compound's unique properties facilitate the synthesis of novel bioactive molecules, particularly in the areas of protease inhibitors and metabolic studies.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially protease inhibitors and enzyme substrates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate fluorinated amino acid residues, altering peptide stability, bioavailability, and binding affinity.
• Biochemical Research: Serves as a tool compound in metabolic pathway studies and enzyme mechanism investigations due to its fluorine label, which can act as a spectroscopic probe or metabolic blocker.
• Agrochemical Development: Potential intermediate in the synthesis of advanced, target-specific herbicides or plant growth regulators that utilize amino acid analogs.
• Diagnostic Agent Precursor: Can be utilized in the development of Positron Emission Tomography (PET) tracers when labeled with fluorine-18, for imaging and diagnostic applications.

Basic Information

Product Name	L-Aspartic Acid, 3-Fluoro-, Threo- (9Ci)
CAS No.	106138-31-2
Molecular Formula	C4H6FNO4
Molecular Weight	151.09 g/mol
Synonyms	(2S,3S)-3-Fluoroaspartic Acid; L-threo-3-Fluoroaspartic Acid; (2S,3S)-2-Amino-3-fluorosuccinic Acid; 3-Fluoro-L-threo-aspartic Acid; 3-Fluoro-DL-aspartic Acid (threo isomer); 3-F-Asp; Fluorinated Aspartic Acid Derivative; 3-Fluoroaspartate
EINECS	Contact for details

Quality Control

Every batch of L-Aspartic Acid, 3-Fluoro-, Threo- (9Ci) is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical research and development projects. A detailed Certificate of Analysis (COA) including chiral purity, assay, and impurity profile is supplied with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); therefore, containers must be kept tightly sealed and desiccated after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (threo, L-configuration)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.