Description

6-Fluoro-3,4-Dihydro-2H-Benzo[1,4]Oxazine Hydrochloride is a high-purity, synthetically derived organic compound that serves as a critical building block in advanced pharmaceutical research and development. Its value lies in its role as a versatile intermediate for constructing complex molecular architectures, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). This compound is essential for medicinal chemists and process development scientists working in the pharmaceutical, agrochemical, and fine chemical industries, where precise chemical functionality is paramount for creating new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for novel organic electronic materials and functional dyes due to its fused heterocyclic structure.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	6-Fluoro-3,4-Dihydro-2H-Benzo[1,4]Oxazine Hydrochloride
CAS No.	105655-00-3
Molecular Formula	C8H9ClFNO
Molecular Weight	189.61 g/mol
Synonyms	6-Fluoro-3,4-dihydro-2H-1,4-benzoxazine hydrochloride; 2H-1,4-Benzoxazine, 6-fluoro-3,4-dihydro-, hydrochloride; 6-Fluoro-2H-1,4-benzoxazine-3(4H)-one hydrochloride (tautomer); 6-Fluorodihydrobenzoxazine HCl; 6-Fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine hydrochloride
EINECS	Contact for details

Quality Control

Our 6-Fluoro-3,4-Dihydro-2H-Benzo[1,4]Oxazine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for each lot, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.