Description

Methyl (2R,3S)-2,3-Epoxy-3-(4-Methoxyphenyl)Propionate is a high-value chiral epoxide building block of significant importance in asymmetric synthesis. Its defined stereochemistry makes it a critical intermediate for constructing complex molecules with precise three-dimensional architecture. This compound is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for the production of active pharmaceutical ingredients (APIs) and advanced agrochemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of enantiomerically pure drugs, particularly in cardiovascular and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced, stereospecific pesticides and herbicides with enhanced efficacy and environmental profiles.
• Asymmetric Catalysis Research: Serves as a standard substrate or ligand precursor in the development and screening of new chiral catalysts.
• Fine Chemical Production: Building block for fragrances, flavors, and other specialty chemicals requiring high stereochemical purity.
• Academic & Industrial R&D: Utilized in process chemistry development and methodological studies for ring-opening reactions and nucleophilic additions.

Basic Information

Product Name	Methyl (2R,3S)-2,3-Epoxy-3-(4-Methoxyphenyl)Propionate
CAS No.	105560-93-8
Molecular Formula	C11H12O4
Molecular Weight	208.21 g/mol
Synonyms	(2R,3S)-Methyl 2,3-Epoxy-3-(4-methoxyphenyl)propanoate; Methyl (2R,3S)-(-)-trans-β-(4-Methoxyphenyl)glycidate; (2R,3S)-(-)-Methyl 4-Methoxyphenylglycidate; (2R,3S)-Methyl oxiran-2-yl(4-methoxyphenyl)acetate; (2R,3S)-Epoxy Methyl P-Methoxyphenylpropionate; trans-Methyl 4-methoxyphenylglycidate; Chiral Methyl Phenylglycidate Derivative
EINECS	Contact for details

Quality Control

Our Methyl (2R,3S)-2,3-Epoxy-3-(4-Methoxyphenyl)Propionate is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric excess (ee). Quality is verified through advanced analytical techniques including chiral HPLC, NMR, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric ratio, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to maintain stability and purity. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.