Description

3'-Bromo-5'-Fluoroacetophenone is a high-purity halogenated acetophenone derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile molecular scaffold for constructing complex pharmaceutical intermediates and agrochemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce specific bromo and fluoro substituents into target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic ketone motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the bromo-fluoro substitution pattern influences bioactivity.
• Liquid Crystal & OLED Material Research: Serves as a starting material for synthesizing halogenated aromatic compounds used in electronic and photonic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine atom.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving diverse client projects.

Basic Information

Item	Detail
Product Name	3'-Bromo-5'-Fluoroacetophenone
CAS No.	105515-20-6
Molecular Formula	C8H6BrFO
Molecular Weight	217.04 g/mol
Synonyms	1-(3-Bromo-5-fluorophenyl)ethanone; 3-Bromo-5-fluoroacetophenone; 1-Acetyl-3-bromo-5-fluorobenzene; 3-Bromo-5-fluorophenyl methyl ketone; 3'-Bromo-5'-fluoroacetophenone; 3-Br-5-F-C6H3COCH3; Ethanone, 1-(3-bromo-5-fluorophenyl)-
EINECS	Contact for details

Quality Control

Our 3'-Bromo-5'-Fluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.