Description

(Z)-1-[5-Amino-1-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan- 2-Yl]Imidazol-4-Yl]-2-Diazonio-Ethenolate is a sophisticated nucleoside analog derivative, a key intermediate in the synthesis of novel antiviral and anticancer agents. Its value lies in its precise stereochemistry and functional groups, which are critical for imparting biological activity and specificity in targeted drug development. This high-purity compound is essential for pharmaceutical R&D teams, medicinal chemists, and fine chemical manufacturers engaged in creating next-generation therapeutics, particularly in the fields of virology and oncology.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of nucleoside-based antiviral drugs and anticancer prodrugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new therapeutic agents targeting viral polymerases or cellular enzymes.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to understand nucleotide metabolism and related pathways.
• Antiviral Agent Development: Core scaffold for developing novel treatments against DNA and RNA viruses.
• Oncology Research: Investigated as a precursor for antimetabolite drugs designed to disrupt DNA synthesis in rapidly dividing cancer cells.
• Labeled Compound Synthesis: Potential starting material for synthesizing isotopically labeled (e.g., C13, N15) compounds for pharmacokinetic and metabolic studies.

Basic Information

Product Name	(Z)-1-[5-Amino-1-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan- 2-Yl]Imidazol-4-Yl]-2-Diazonio-Ethenolate
CAS No.	105400-24-6
Molecular Formula	C10H14N6O5
Molecular Weight	298.26 g/mol
Synonyms	5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carboxamide diazonium betaine; 5-Amino-1-β-D-ribofuranosylimidazole-4-carboxamide diazonium inner salt; AICAR Diazonium Betaine; AICA-riboside diazonium derivative; (Z)-1-[5-Amino-1-(β-D-ribofuranosyl)-1H-imidazol-4-yl]-2-diazonioethenolate; 5-Aminoimidazole-4-carboxamide ribonucleoside diazonium salt; AICAR diazoate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chemical purity, suitable for demanding research and development applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development under cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. This compound is strictly light-sensitive and hygroscopic; all handling and aliquoting should be performed in a controlled, moisture-free environment with minimal exposure to light. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.