Description

o-Tolyl(Trimethylsilylethynyl) Ketone is a specialized organosilicon building block featuring a ketone group and a protected acetylene moiety. This compound is valued for its role as a key intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as cross-coupling reactions and the synthesis of novel functional molecules.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry research.
• Agrochemical Synthesis: Used in the research and production of novel pesticides, herbicides, and plant growth regulators.
• Material Science Precursor: Serves as a building block for advanced organic materials, including polymers, liquid crystals, and organic electronic components.
• Cross-Coupling Reactions: The trimethylsilylethynyl group acts as a protected alkyne, readily deprotected for use in Sonogashira and other palladium-catalyzed coupling reactions.
• Academic & Industrial R&D: Employed in research laboratories for methodological development and the synthesis of complex natural product analogs or novel chemical entities.
• Fine Chemical Production: Integral to the multi-step synthesis of high-value, low-volume specialty chemicals and performance materials.

Basic Information

Product Name	o-Tolyl(Trimethylsilylethynyl) Ketone
CAS No.	105364-94-1
Molecular Formula	C13H16OSi
Molecular Weight	216.35 g/mol
Synonyms	1-(2-Methylphenyl)-3-(trimethylsilyl)-2-propyn-1-one; 2-Methylbenzoyl(trimethylsilyl)acetylene; (2-Methylbenzoyl)(trimethylsilyl)acetylene; o-Tolyl(trimethylsilyl)ethynyl ketone; 2-Methylbenzoyltrimethylsilylacetylene; 1-(2-Methylphenyl)-3-(trimethylsilyl)prop-2-yn-1-one; Ketone, o-tolyl(trimethylsilylethynyl); TMS-protected o-tolyl ethynyl ketone
EINECS	Contact for details

Quality Control

Our o-Tolyl(Trimethylsilylethynyl) Ketone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.