Description

3,4,5-Tribromoacetophenone is a specialized brominated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in pharmaceutical and agrochemical research where the introduction of bromine atoms is crucial for modulating biological activity and material properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders or possessing antimicrobial properties.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides, where the tribromophenacyl moiety can enhance efficacy.
• Material Science Research: Acts as a building block for synthesizing specialty polymers, liquid crystals, or organic electronic materials due to its bulky, electron-withdrawing character.
• Chemical Biology Probes: Employed in the creation of molecular probes and tags for studying enzyme activity or protein interactions.
• Organic Synthesis Reagent: Functions as a versatile electrophile in Friedel-Crafts acylations and nucleophilic substitution reactions to introduce functionalized acetophenone groups.
• Flame Retardant Research: Investigated as a potential intermediate or additive component in the development of flame-retardant materials, leveraging its high bromine content.

Basic Information

Product Name	3,4,5-Tribromoacetophenone
CAS No.	104892-58-2
Molecular Formula	C8H5Br3O
Molecular Weight	340.84 g/mol
Synonyms	1-(3,4,5-Tribromophenyl)ethanone; 3,4,5-Tribromoacetophenone; 3',4',5'-Tribromoacetophenone; Ethanone, 1-(3,4,5-tribromophenyl)-; Tribromoacetophenone; Acetophenone, 3,4,5-tribromo-; 3,4,5-Tribromo-1-acetylbenzene
EINECS	Contact for details

Quality Control

Our 3,4,5-Tribromoacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.