Description

Bryostatin A is a potent, naturally occurring macrocyclic lactone with significant biological activity, originally isolated from the marine bryozoan *Bugula neritina*. This compound is of paramount importance in biomedical research due to its unique mechanism of action as a modulator of protein kinase C (PKC). It is primarily sought after by research institutions and pharmaceutical developers engaged in advanced studies for oncology, neurology, and immunology. The global availability of Bryostatin A CAS NO 104841-29-4 supports critical investigations into novel therapeutic pathways.

Application

• Oncology Research: Investigated for its potential as an anti-cancer agent, particularly in leukemia, melanoma, and renal cell carcinoma studies.
• Neurological Disorder Studies: Explored for neuroprotective and cognitive-enhancing effects in models of Alzheimer's disease, stroke, and spinal cord injury.
• Immunology and HIV Research: Studied for its ability to activate latent HIV reservoirs and modulate immune cell function.
• Chemical Biology: Used as a highly specific probe to study PKC signaling pathways and intracellular communication.
• Drug Discovery & Preclinical Development: Serves as a lead compound or reference standard in the development of new PKC-targeting pharmaceuticals.
• Academic & Institutional Research: Fundamental research tool in universities and government labs for studying cell proliferation, differentiation, and apoptosis.

Basic Information

Product Name	Bryostatin A
CAS No.	104841-29-4
Molecular Formula	C47H68O17
Molecular Weight	905.03 g/mol
Synonyms	Bryostatin 1; NSC 339555; (1S,3S,4S,5R,7S,8S,9S,14S,15R,16S,20R)-5,7,9,14,15,16-Hexahydroxy-4,8,15-trimethyl-3-[(1E)-1-propen-1-yl]-20-[[(2S,3S,4R,5S)-3,4,5-trihydroxy-6-methyl-2-oxanyl]oxy]-1-oxacycloeicos-11-ene-2,6,10,19-tetrone; Bryostatin A1
EINECS	Contact for details

Quality Control

Our Bryostatin A is produced and handled under strict quality management protocols to ensure the integrity and reproducibility required for high-level research. Each batch is characterized using advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and potency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details
Biological Activity (PKC Binding)	Reported

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.