Description

(2S,3S)-(-)-3-Phenylglycidol is a high-value chiral epoxide building block of significant importance in asymmetric synthesis. Its stereochemically defined structure makes it a critical precursor for the production of enantiomerically pure pharmaceuticals and fine chemicals. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity chiral intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of β-blockers, HIV protease inhibitors, and other active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators where biological activity is stereospecific.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the preparation of chiral ligands and catalysts used in enantioselective transformations.
• Fine Chemical Production: Employed in the synthesis of complex natural products, flavors, fragrances, and advanced materials that demand high optical purity.
• Academic & Process R&D: A valuable reagent for method development in organic synthesis and scale-up studies within research laboratories.

Basic Information

Product Name	(2S,3S)-(-)-3-Phenylglycidol
CAS No.	104196-23-8
Molecular Formula	C9H10O2
Molecular Weight	150.17 g/mol
Synonyms	(-)-(2S,3S)-3-Phenylglycidol; (2S,3S)-3-Phenyloxiranemethanol; (2S,3S)-Phenylglycidol; (2S,3S)-(-)-Phenylglycidol; trans-(-)-2-Phenyl-3-hydroxymethyloxirane; (2S,3S)-2-(Hydroxymethyl)-3-phenyloxirane; (2S,3S)-3-Phenyl-1,2-epoxy-3-propanol
EINECS	Contact for details

Quality Control

Our (2S,3S)-(-)-3-Phenylglycidol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, specific rotation, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Specific Rotation ([α]D20)	-30° to -35° (c=1 in CHCl3)
Melting Point	65 - 70 °C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.