Description

8-Fluoroerythronolide A is a strategically fluorinated derivative of the erythronolide A macrolide core, a key intermediate in the synthesis of advanced macrolide antibiotics. This modification introduces a fluorine atom at the C-8 position, a critical site for modulating biological activity, metabolic stability, and binding affinity in final pharmaceutical compounds. It is an essential building block for medicinal chemistry research and process development teams in the pharmaceutical and biotechnology sectors focused on next-generation anti-infective agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the semi-synthesis of novel fluorinated macrolide antibiotics, such as advanced telithromycin analogs.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to explore the impact of C-8 fluorination on potency and pharmacokinetics.
• Process Chemistry & Scale-Up: Serves as a validated intermediate for developing and optimizing robust, scalable synthetic routes to complex macrolides.
• Reference Standard: Employed as an analytical standard for quality control and impurity profiling in the manufacture of related antibiotic APIs.
• Biochemical Tool Compound: Utilized in microbiological and enzymatic studies to investigate mechanisms of action and resistance in bacterial systems.

Basic Information

Product Name	8-Fluoroerythronolide A
CAS No.	104160-68-1
Molecular Formula	C21H35FO7
Molecular Weight	418.50 g/mol
Synonyms	8-Fluoro-6-deoxyerythronolide B; 8-Fluoro-6,12-dideoxyerythronolide B; 8-Fluoroerythronolide; (3R,5S,6S,7R,8R,9S,11R,12S,13S,14R)-8-Fluoro-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-4-oxooxacyclotetradecane-2,6-dione; Erythronolide A, 8-fluoro-; 8-F-EryA
EINECS	Contact for details

Quality Control

Our 8-Fluoroerythronolide A is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. While produced to meet exacting internal standards, specifications can be aligned with customer-specific requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single unknown impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.