Description

1-Hydroxy-1,2,3,4-Tetrahydronaphthalene-2-Carboxylic Acid is a functionalized tetralin derivative that serves as a versatile chiral building block and synthetic intermediate. This compound is valued for its rigid, fused-ring structure which is instrumental in the synthesis of complex molecules with defined stereochemistry. It is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries for applications in medicinal chemistry and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular targets.
• Asymmetric Synthesis: Utilized as a precursor or auxiliary in stereoselective reactions to construct complex molecular architectures.
• Ligand and Catalyst Development: Serves as a core structure for designing novel chiral ligands and organocatalysts.
• Material Science Research: Investigated as a monomer or additive for creating specialized polymers with unique thermal or optical properties.
• Academic & Industrial R&D: Employed in methodological studies and process chemistry for route scouting and optimization.

Basic Information

Product Name	1-Hydroxy-1,2,3,4-Tetrahydronaphthalene-2-Carboxylic Acid
CAS No.	103986-79-4
Molecular Formula	C11H12O3
Molecular Weight	192.21 g/mol
Synonyms	1-Hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid; 2-Carboxy-1-hydroxy-1,2,3,4-tetrahydronaphthalene; 1,2,3,4-Tetrahydro-1-hydroxy-2-naphthoic acid; 1-Hydroxy-2-naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-; Tetralin-2-carboxylic acid, 1-hydroxy-; (1R,2S)-rel-1-Hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid (racemic mixture); 1,2,3,4-Tetrahydro-1-hydroxy-2-naphthalenecarboxylic acid
EINECS	Contact for details

Quality Control

Our 1-Hydroxy-1,2,3,4-Tetrahydronaphthalene-2-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.