Description

(3E,5R,12R)-5-Hydroxy-12-Methyl-1-Oxa-3-Cyclododecene-2-One is a high-purity, chiral macrolide building block of significant interest in advanced organic synthesis. This compound matters for its precise stereochemistry and functional group arrangement, making it a valuable intermediate for constructing complex molecular architectures. It is primarily needed by research chemists and process development teams in the pharmaceutical and fine chemical industries for applications such as the synthesis of novel active pharmaceutical ingredients (APIs) and fragrances.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel macrolide antibiotics and other therapeutic agents.
• Fine Chemical Synthesis: Used in the construction of complex natural product analogs and specialty molecules for agrochemical and material science research.
• Asymmetric Catalysis Research: Serves as a sophisticated substrate or ligand precursor in the development of new stereoselective catalytic reactions.
• Fragrance and Flavor Chemistry: Acts as a building block for synthesizing macrocyclic musk compounds and other complex odorants.
• Academic and R&D Laboratories: Employed in methodological studies and for training purposes in advanced organic synthesis techniques.
• Process Chemistry Development: Used to scale up and optimize synthetic routes for target molecules requiring this specific stereochemical framework.

Basic Information

Product Name	(3E,5R,12R)-5-Hydroxy-12-Methyl-1-Oxa-3-Cyclododecene-2-One
CAS No.	103729-44-8
Molecular Formula	C₁₂H₂₀O₃
Molecular Weight	212.29 g/mol
Synonyms	5-Hydroxy-12-methyl-1-oxa-3-cyclododecene-2-one, (3E,5R,12R)-; (-)-Pyrenophorin; (5R,12R)-5-Hydroxy-12-methyl-1-oxacyclododec-3-en-2-one; 12-Methyl-5-hydroxy-1-oxa-3-cyclododecene-2-one; Macrolide fragment; Pyrenophorin derivative; (3E,5R,12R)-form; Optically active macrolactone intermediate
EINECS	Contact for details

Quality Control

Our (3E,5R,12R)-5-Hydroxy-12-Methyl-1-Oxa-3-Cyclododecene-2-One is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We support compliance with cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.