Description

Methanone, (1-Fluorocyclopropyl)(4-Methylphenyl)- (9Ci) is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the 1-fluorocyclopropyl moiety adjacent to the carbonyl group, enabling precise structural modifications. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries who require high-purity intermediates for constructing complex molecular architectures.

Application

This fluorinated methanone derivative serves as a versatile intermediate in several high-value synthetic pathways.

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, where the fluorocyclopropyl group can enhance biological activity and environmental stability.
• Material Science Precursor: Employed in the synthesis of specialty polymers and liquid crystals, where its rigid, fluorinated structure can influence material properties.
• Medicinal Chemistry: A crucial scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fluorine Chemistry: Serves as a model compound for studying the electronic and steric effects of the fluorinated cyclopropane ring in ketone chemistry.

Basic Information

Product Name	Methanone, (1-Fluorocyclopropyl)(4-Methylphenyl)- (9Ci)
CAS No.	103543-84-6
Molecular Formula	C11H11FO
Molecular Weight	178.20 g/mol
Synonyms	(1-Fluorocyclopropyl)(p-tolyl)methanone; 1-Fluorocyclopropyl 4-methylphenyl ketone; p-Tolyl 1-fluorocyclopropyl ketone; (4-Methylphenyl)(1-fluorocyclopropyl)methanone; 1-Fluoro-1-(4-methylbenzoyl)cyclopropane
EINECS	Contact for details

Quality Control

Our production of Methanone, (1-Fluorocyclopropyl)(4-Methylphenyl)- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and purity for critical research and development applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.