Description

Methanone, (1-Fluorocyclopropyl)(4-Fluorophenyl)- (9Ci) is a specialized fluorinated ketone building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a fluorinated cyclopropyl and a fluorinated phenyl ring, makes it a valuable precursor for creating novel compounds with tailored properties. This high-purity intermediate is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries. Its application is critical for the development of new active ingredients where the introduction of fluorine atoms can modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorinated motifs can enhance biological activity and environmental persistence profiles.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers and advanced materials with specific thermal, chemical, or surface properties.
• Ligand & Catalyst Development: Employed in organometallic chemistry for the creation of novel fluorinated ligands used in asymmetric catalysis and transition metal complexes.
• Fluorine Chemistry Research: An essential compound for academic and industrial research focused on exploring new methodologies in fluorination and the study of structure-activity relationships (SAR).
• Diagnostic Agent Synthesis: Potential use in the development of fluorinated contrast agents or radiotracers for medical imaging techniques such as PET (Positron Emission Tomography).

Basic Information

Product Name	Methanone, (1-Fluorocyclopropyl)(4-Fluorophenyl)- (9Ci)
CAS No.	103543-82-4
Molecular Formula	C10H8F2O
Molecular Weight	182.17 g/mol
Synonyms	(1-Fluorocyclopropyl)(4-fluorophenyl)methanone; 4-Fluorophenyl 1-fluorocyclopropyl ketone; 1-Fluorocyclopropyl 4-fluorophenyl ketone; (4-Fluorophenyl)(1-fluorocyclopropyl)methanone; 1-Fluoro-1-(4-fluorobenzoyl)cyclopropane; 103543-82-4; (1-Fluorocyclopropyl)-(4-fluorophenyl)-methanone
EINECS	Contact for details

Quality Control

Our Methanone, (1-Fluorocyclopropyl)(4-Fluorophenyl)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to quality supports applications in cGMP-compliant research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.