Description

(+)-(3R,7As)-Tetrahydro-3-Phenyl-3H,5H-Pyrrolo1,2-Coxaole-5-One is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. Its defined stereochemistry and unique fused oxazole-pyrrolidine structure make it a critical precursor for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for research and manufacturing in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of complex drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides with specific stereochemical activity.
• Catalyst & Ligand Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric catalysis.
• Academic & Industrial R&D: A valuable compound for methodological studies in organic synthesis and medicinal chemistry research.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals requiring a high degree of stereochemical purity.

Basic Information

Product Name	(+)-(3R,7As)-Tetrahydro-3-Phenyl-3H,5H-Pyrrolo1,2-Coxaole-5-One
CAS No.	103201-79-2
Molecular Formula	C12H13NO2
Molecular Weight	203.24 g/mol
Synonyms	(3R,7aS)-3-Phenyltetrahydro-1H,3H-pyrrolo[1,2-c]oxazol-1-one; (3R,7aS)-Tetrahydro-3-phenylpyrrolo[1,2-c]oxazol-1(3H)-one; (+)-3-Phenyltetrahydropyrrolo[1,2-c]oxazol-1-one; (R)-3-Phenyltetrahydropyrrolo[1,2-c]oxazol-1-one; (3R,7aS)-3-Phenyl-2,3,6,7a-tetrahydro-1H-pyrrolo[1,2-c]oxazol-1-one; Chiral Oxazolidinone Derivative; 103201-79-2
EINECS	Contact for details

Quality Control

Our (+)-(3R,7As)-Tetrahydro-3-Phenyl-3H,5H-Pyrrolo1,2-Coxaole-5-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis (HPLC, Chiral GC), identity confirmation (IR, NMR), and impurity profiling to ensure it meets exacting research and GMP-grade standards. A detailed Certificate of Analysis (COA) specifying purity, enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.