Description

(3R)-3α-Chloro-6,8-Dihydroxy-3,10A-Dihydro-2,2-Dimethyl-10Aβ-[[(1R,3S)-2,2-Dimethyl-3-Chloro-6-Methylenecyclohexyl]Methyl]-2H-Naphtho[2,3-B]Pyran-5,10-Dione is a complex, high-purity synthetic intermediate characterized by its fused naphthopyran-dione structure with multiple chiral centers. This compound matters for its role as a key building block in the synthesis of advanced pharmaceutical agents and bioactive molecules, where precise stereochemistry is critical for biological activity. It is primarily needed by research institutions and pharmaceutical development teams focused on creating novel therapeutics, particularly in oncology and anti-infective research.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel drug candidates, especially those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological profile of new chemical entities.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for potential Active Pharmaceutical Ingredient (API) manufacturing.
• Reference Standard: Provides a high-purity benchmark for analytical method development, validation, and quality control in research and development settings.
• Biochemical Probe Synthesis: Utilized to create specialized tools for investigating biological mechanisms and target identification.

Basic Information

Product Name	(3R)-3α-Chloro-6,8-Dihydroxy-3,10A-Dihydro-2,2-Dimethyl-10Aβ-[[(1R,3S)-2,2-Dimethyl-3-Chloro-6-Methylenecyclohexyl]Methyl]-2H-Naphtho[2,3-B]Pyran-5,10-Dione
CAS No.	103106-21-4
Molecular Formula	C25H28Cl2O5
Molecular Weight	479.39 g/mol
Synonyms	3α-Chloro-6,8-dihydroxy-3,10a-dihydro-2,2-dimethyl-10aβ-[[(1R,3S)-2,2-dimethyl-3-chloro-6-methylenecyclohexyl]methyl]-2H-naphtho[2,3-b]pyran-5,10-dione; (3R)-3α-Chloro-6,8-dihydroxy-3,10a-dihydro-2,2-dimethyl-10aβ-[[(1R,3S)-2,2-dimethyl-3-chloro-6-methylenecyclohexyl]methyl]-2H-naphtho[2,3-b]pyran-5,10-dione; Naphtho[2,3-b]pyran-5,10-dione derivative; CAS 103106-21-4; 103106-21-4; (3R,10aβ)-3α-Chloro-6,8-dihydroxy-3,10a-dihydro-2,2-dimethyl-10a-[[(1R,3S)-2,2-dimethyl-3-chloro-6-methylenecyclohexyl]methyl]-2H-naphtho[2,3-b]pyran-5,10-dione
EINECS	Contact for details

Quality Control

Our (3R)-3α-Chloro-6,8-Dihydroxy-3,10A-Dihydro-2,2-Dimethyl-10Aβ-[[(1R,3S)-2,2-Dimethyl-3-Chloro-6-Methylenecyclohexyl]Methyl]-2H-Naphtho[2,3-B]Pyran-5,10-Dione is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity (HPLC), chiral purity, and impurity profiles is provided with every shipment to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.