Description

Proline, 4-Ethyl-3-(Hydroxymethyl)- (9Ci) is a specialized proline derivative, a non-natural amino acid analog of significant interest in advanced organic synthesis and pharmaceutical research. Its unique structure, featuring an ethyl group and a hydroxymethyl substituent on the proline ring, makes it a valuable chiral building block for constructing complex molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications such as peptide mimetics, catalyst ligands, and medicinal chemistry intermediates.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other biologically active peptides.
• Peptidomimetics & Drug Design: Used to create constrained peptide analogs and peptidomimetics to enhance metabolic stability, bioavailability, and receptor selectivity.
• Catalyst & Ligand Synthesis: Acts as a precursor for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and plant growth regulators that utilize amino acid-based chemistry.
• Bioconjugation & Probe Development: Useful for introducing functional handles into biomolecules for labeling, imaging, or targeted delivery applications.
• Fine Chemical Synthesis: A versatile building block for the custom synthesis of complex, high-value specialty chemicals for various industrial research programs.

Basic Information

Item	Detail
Product Name	Proline, 4-Ethyl-3-(Hydroxymethyl)- (9Ci)
CAS No.	102686-07-7
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	4-Ethyl-3-(hydroxymethyl)proline; 3-(Hydroxymethyl)-4-ethylproline; 4-Ethyl-3-hydroxymethylproline; (3S,4S)-4-Ethyl-3-(hydroxymethyl)pyrrolidine-2-carboxylic acid; 4-Ethyl-3-hydroxymethyl-L-proline; 4-Ethyl-3-(hydroxymethyl)-L-proline; 4-Ethyl-3-(hydroxymethyl)-D-proline (enantiomer); Proline derivative with ethyl and hydroxymethyl substituents
EINECS	Contact for details

Quality Control

Our Proline, 4-Ethyl-3-(Hydroxymethyl)- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to ensure structural integrity and enantiomeric purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, assay, and impurity profiles. We support cGMP standards for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (specify enantiomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.