Description

2-Bromo-2',4'-Difluoroacetophenone is a versatile and highly functionalized aromatic ketone building block, distinguished by its bromine and fluorine substituents. This compound is crucial for its role as a key intermediate in advanced organic synthesis, particularly in the construction of complex molecules for pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications such as cross-coupling reactions and the synthesis of biologically active heterocycles.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated and brominated aromatic systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the difluorophenyl moiety enhances biological activity and metabolic stability.
• Cross-Coupling Reactions: Serves as an excellent electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Material Science Research: Employed in the creation of specialty monomers and ligands for catalysts or advanced polymeric materials.
• Chemical Biology Probes: Utilized as a building block for synthesizing molecular probes and tags used in biochemical assays and diagnostic research.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Product Name	2-Bromo-2',4'-Difluoroacetophenone
CAS No.	102429-07-2
Molecular Formula	C8H5BrF2O
Molecular Weight	235.03 g/mol
Synonyms	1-(2-Bromo-2,4-difluorophenyl)ethanone; 2'-Bromo-2,4'-difluoroacetophenone; α-Bromo-2,4-difluoroacetophenone; 2-Bromo-1-(2,4-difluorophenyl)ethan-1-one; Ethanone, 1-(2-bromo-2,4-difluorophenyl)-; 2,4-Difluoro-2-bromoacetophenone; 2-Bromo-2,4-difluoroacetophenone
EINECS	Contact for details

Quality Control

Our 2-Bromo-2',4'-Difluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.