Description

1,3-Dioxolane, 2-Ethynyl-4,5-Dimethyl-, [4R-(2Alpha,4Alpha,5Beta)]- (9Ci) is a specialized chiral building block featuring a dioxolane ring with an ethynyl substituent. This compound matters for its role as a key intermediate in the synthesis of complex, stereochemically defined molecules, particularly in pharmaceutical research and development. It is needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where specific stereochemistry is required for biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of advanced polymers and functional materials with tailored optical or electronic properties.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and for exploring new chemical spaces in drug discovery programs.

Basic Information

Product Name	1,3-Dioxolane, 2-Ethynyl-4,5-Dimethyl-, [4R-(2Alpha,4Alpha,5Beta)]- (9Ci)
CAS No.	102276-19-7
Molecular Formula	C7H10O2
Molecular Weight	126.15 g/mol
Synonyms	2-Ethynyl-4,5-dimethyl-1,3-dioxolane, (4R-cis)-; (4R,5S)-2-Ethynyl-4,5-dimethyl-1,3-dioxolane; (2R,4S,5R)-2-Ethynyl-4,5-dimethyl-1,3-dioxolane; 1,3-Dioxolane, 2-ethynyl-4,5-dimethyl-, (4R-cis)-; cis-2-Ethynyl-4,5-dimethyl-1,3-dioxolane; Chiral ethynyldioxolane; 102276-19-7
EINECS	Contact for details

Quality Control

Our high-purity chiral intermediates are produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including Chiral HPLC to confirm enantiomeric excess and standard techniques (GC, NMR) to verify chemical purity and identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use to prevent evaporation and potential concentration changes.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.