Description

3-Phenylpropenoic Acid (1S,2R,3S,4R,6E,10S)-2-Hydroxy-6,10-Dimethyl-3-(1-Methylethyl)-11-Oxabicyclo[8.1.0]Undec-6-En-4-Yl Ester is a complex, high-purity synthetic intermediate characterized by its intricate bicyclic and esterified structure. This compound matters for its role as a key chiral building block in advanced organic synthesis, enabling the construction of molecules with precise stereochemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), fragrances, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the multi-step synthesis of complex drug candidates, particularly in oncology and anti-inflammatory research.
• Asymmetric Synthesis: Utilized as a sophisticated starting material or coupling agent in catalytic asymmetric reactions to introduce specific stereocenters.
• Fragrance & Flavor Chemistry: Acts as a building block for the synthesis of novel, high-value aroma chemicals with unique olfactory properties.
• Academic & Process R&D: Employed in university and industrial laboratories for methodological studies and scale-up process development.
• Material Science Research: Investigated as a monomer or functional additive for creating specialized polymers with tailored properties.

Basic Information

Product Name	3-Phenylpropenoic Acid (1S,2R,3S,4R,6E,10S)-2-Hydroxy-6,10-Dimethyl-3-(1-Methylethyl)-11-Oxabicyclo[8.1.0]Undec-6-En-4-Yl Ester
CAS No.	102273-85-8
Molecular Formula	C24H32O4
Molecular Weight	384.51 g/mol
Synonyms	(1S,2R,3S,4R,6E,10S)-2-Hydroxy-6,10-dimethyl-3-(1-methylethyl)-11-oxabicyclo[8.1.0]undec-6-en-4-yl 3-phenylprop-2-enoate; Cinnamic Acid (1S,2R,3S,4R,6E,10S)-2-Hydroxy-6,10-Dimethyl-3-(1-Methylethyl)-11-Oxabicyclo[8.1.0]Undec-6-En-4-Yl Ester; (6E)-2-Hydroxy-6,10-dimethyl-3-(propan-2-yl)-11-oxabicyclo[8.1.0]undec-6-en-4-yl cinnamate; Bicyclic Cinnamate Ester; 102273-85-8
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development projects with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.