Description

4'-(1,1,2,2-Tetrafluoroethoxy)Acetophenone is a high-value fluorinated aromatic ketone intermediate, distinguished by its unique tetrafluoroethoxy substituent. This compound is critical for introducing fluorine-containing motifs into target molecules, enhancing their metabolic stability, lipophilicity, and binding affinity. It is primarily sought after by R&D and process chemists in the pharmaceutical and advanced materials sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and specialty polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in developing advanced herbicides and pesticides where the fluorinated group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic display technologies.
• Polymer Modification: Incorporates fluorinated segments into polymers to impart unique surface properties, chemical resistance, and thermal stability.
• Organic Synthesis & Catalysis: A versatile reagent in cross-coupling reactions and as a substrate for developing new fluorination methodologies.
• Advanced Material Research: Employed in R&D for creating novel fluorinated coatings and specialty chemicals.

Basic Information

Product Name	4'-(1,1,2,2-Tetrafluoroethoxy)Acetophenone
CAS No.	101975-15-9
Molecular Formula	C10H8F4O2
Molecular Weight	236.16 g/mol
Synonyms	1-[4-(1,1,2,2-Tetrafluoroethoxy)phenyl]ethanone; 4-(1,1,2,2-Tetrafluoroethoxy)acetophenone; 4'-Tetrafluoroethoxyacetophenone; p-(1,1,2,2-Tetrafluoroethoxy)acetophenone; 4-Acetylphenyl 1,1,2,2-tetrafluoroethyl ether; Ethanone, 1-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-; CAS 101975-15-9
EINECS	Contact for details

Quality Control

Our 4'-(1,1,2,2-Tetrafluoroethoxy)Acetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.