Description

(L)-2-Diazoacetyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, chiral diazo compound used as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile precursor in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel active compounds and intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors and other biologically active molecules.
• Peptidomimetic Research: Used in the construction of peptidomimetic scaffolds to modulate protein-protein interactions.
• Asymmetric Synthesis: Serves as a precursor for chiral metal carbenoids in catalytic asymmetric cyclopropanation and C-H insertion reactions.
• API Development: Employed in the research and process development of new Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Utilized in the synthesis of activity-based probes and other tools for studying enzyme function.
• Agrochemical Synthesis: Acts as an intermediate in the development of novel, chiral agrochemicals.

Basic Information

Product Name	(L)-2-Diazoacetyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	101130-03-4
Molecular Formula	C11H17N3O3
Molecular Weight	239.27 g/mol
Synonyms	Boc-D-Pro-Diazoketone; (S)-2-Diazo-1-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)ethan-1-one; tert-Butyl (2S)-2-(2-diazoacetyl)pyrrolidine-1-carboxylate; (S)-1-(1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)-2-diazoethan-1-one; Boc-L-Pro-Diazoketone; (L)-Boc-Pro-Diazoketone; 1-Boc-2-diazoacetyl-L-proline tert-butyl ester
EINECS	Contact for details

Quality Control

Our (L)-2-Diazoacetyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light yellow solid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.