Description

20-Oxo-20-Deoxyphorbol 12,13-Dibutyrate is a high-purity, semi-synthetic derivative of the phorbol ester family, known for its potent biological activity. This compound serves as a critical reference standard and research-grade biochemical for investigating protein kinase C (PKC) signaling pathways and related cellular mechanisms. It is essential for researchers and developers in the pharmaceutical and life sciences sectors requiring precise, high-quality tools for drug discovery and biochemical studies.

Application

• Biochemical Research: A key tool for studying the activation and modulation of Protein Kinase C (PKC) isoforms in cell signaling experiments.
• Pharmaceutical Development: Used as a reference standard and pharmacological probe in the discovery and validation of novel therapeutic agents targeting PKC-related diseases.
• Cell Biology Studies: Employed to induce specific cellular responses, such as tumor promotion in mechanistic studies, to understand carcinogenesis and cell proliferation.
• Academic Research: Serves as a vital reagent in university and institutional labs for fundamental research in signal transduction and molecular biology.
• Toxicology Screening: Utilized as a model compound for assessing the biological impact of phorbol esters and related structures.

Basic Information

Item	Details
Product Name	20-Oxo-20-Deoxyphorbol 12,13-Dibutyrate
CAS No.	100930-03-8
Molecular Formula	C32H46O8
Molecular Weight	558.71 g/mol
Synonyms	20-Oxo-20-deoxyphorbol 12,13-dibutyrate; 12,13-Dibutyryl-20-deoxy-20-oxophorbol; 20-Deoxy-20-oxophorbol 12,13-dibutyrate; NSC 334153; Phorbol 12,13-dibutyrate 20-oxo-20-deoxy derivative; 20-Oxo-20-deoxyphorbol-12,13-dibutanoate
EINECS	Contact for details

Quality Control

Every batch of 20-Oxo-20-Deoxyphorbol 12,13-Dibutyrate is manufactured and tested under strict quality management systems to ensure identity, purity, and consistency. Our products undergo rigorous analytical testing, including HPLC and NMR, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.