Description

3-(Chloro-Difluoro-Methyl)-4,4,4-Trifluoro-3-Hydroxy-Butanal is a high-value fluorinated organic intermediate characterized by its unique trifluoromethyl and chlorodifluoromethyl functional groups. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceuticals and agrochemicals, where its fluorine atoms impart desirable properties like metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the fluorine content enhances biological activity and environmental persistence.
• Fluorinated Material Precursor: Serves as a starting material for synthesizing specialty polymers, liquid crystals, and advanced materials requiring specific fluorochemical properties.
• Organic Synthesis Building Block: Employed in academic and industrial research for constructing complex molecules via reactions involving its aldehyde and hydroxy functional groups.

Basic Information

Product Name	3-(Chloro-Difluoro-Methyl)-4,4,4-Trifluoro-3-Hydroxy-Butanal
CAS No.	100482-83-5
Molecular Formula	C5H4ClF5O2
Molecular Weight	226.53 g/mol
Synonyms	4,4,4-Trifluoro-3-hydroxy-3-[(chlorodifluoromethyl)butanal; 3-Hydroxy-3-(chlorodifluoromethyl)-4,4,4-trifluorobutanal; 1,1,1-Trifluoro-4-chloro-4,4-difluoro-3-hydroxy-2-butanone (tautomer); α-(Chlorodifluoromethyl)-β-hydroxy-β-trifluoromethylpropionaldehyde; CF3C(OH)(CHClF2)CHO; Fluorinated hydroxy aldehyde intermediate
EINECS	Contact for details

Quality Control

Our 3-(Chloro-Difluoro-Methyl)-4,4,4-Trifluoro-3-Hydroxy-Butanal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its properties of being easily oxidized and highly volatile, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability and to minimize decomposition. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.