Description

2-Chloro-5-Iodoacetophenone is a versatile halogenated acetophenone derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both chloro and iodo substituents, makes it a valuable building block for constructing complex molecules with specific electronic and steric properties. This compound is primarily utilized by research institutions and pharmaceutical development companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic motifs.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and pesticides where the halogen atoms are crucial for bioactivity.
• Material Science Research: Used in the development of organic semiconductors, liquid crystals, and photoactive materials due to its electron-withdrawing characteristics.
• Chemical Biology Probes: Serves as a starting material for creating molecular probes and tags for studying biological processes.
• Cross-Coupling Reactions: The iodo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl structures.
• Organic Synthesis Research: A valuable reagent for academic and industrial R&D labs exploring new synthetic methodologies and heterocyclic compound formation.

Basic Information

Product Name	2-Chloro-5-Iodoacetophenone
CAS No.	100479-73-0
Molecular Formula	C8H6ClIO
Molecular Weight	280.49 g/mol
Synonyms	1-(2-Chloro-5-iodophenyl)ethanone; 2'-Chloro-5'-iodoacetophenone; 2-Chloro-5-iodoacetophenone; 1-Acetyl-2-chloro-5-iodobenzene; Ethanone, 1-(2-chloro-5-iodophenyl)-; Acetophenone, 2-chloro-5-iodo-; (2-Chloro-5-iodophenyl)methyl ketone
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Iodoacetophenone is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing specific results for identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.