Description

2,4-Difluorothiophene CAS NO 19259-13-3 is a versatile fluorinated heterocyclic building block, prized for its unique electronic properties and reactivity. This compound is essential for introducing the thiophene moiety with fluorine substitution into complex molecular architectures, enabling fine-tuning of material properties. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly in the development of active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in fluorine-containing drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the difluorothiophene core enhances biological activity and stability.
• Organic Electronic Materials: A fundamental building block for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Liquid Crystal & Display Technology: Serves as a core component in the synthesis of fluorinated liquid crystals for high-performance displays.
• Chemical Research & Development: A valuable reagent in organic synthesis for cross-coupling reactions, such as Suzuki and Stille couplings, to create complex heterocyclic systems.
• Coordination Chemistry & Ligand Design: Used to prepare specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2,4-Difluorothiophene
CAS No.	19259-13-3
Molecular Formula	C4H2F2S
Molecular Weight	120.12 g/mol
Synonyms	2,4-Difluorothiophene; Thiophene, 2,4-difluoro-; 2,4-Difluoro-thiophene; 2,4-Difluorothiofuran; 2,4-Difluoro-1-thia-2,4-cyclopentadiene; 19259-13-3
EINECS	Contact for details

Quality Control

Our 2,4-Difluorothiophene is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for industrial and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place, away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed at temperatures between 15-25°C. Keep under an inert atmosphere if prolonged storage is required.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	≤ 2.0% total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.