Description

Pentafluorophenyl Acetate is a high-purity fluorinated aromatic ester, a versatile reagent and building block in advanced organic synthesis. Its primary value lies in its highly reactive pentafluorophenyl (PFP) ester group, which serves as an excellent leaving group for amide and peptide bond formation under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing active pharmaceutical ingredients (APIs), peptide conjugates, and complex molecular scaffolds.

Application

• Peptide Synthesis & Bioconjugation: As an activated ester for efficient, racemization-free coupling of amino acids and peptides.
• Pharmaceutical Intermediate: A key building block in the synthesis of fluorinated drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in creating novel fluorinated pesticides and herbicides with enhanced biological activity and stability.
• Material Science: Serves as a monomer or modifier for synthesizing fluorinated polymers and advanced materials with unique surface properties.
• Proteomics Research: Employed in chemical proteomics for activity-based protein profiling (ABPP) and labeling studies.
• Cross-linking Agent: Utilized in the preparation of cross-linked biomaterials and hydrogels.
• Derivatization Reagent: For analytical chemistry applications, including the derivatization of amines and alcohols for GC or LC-MS analysis.

Basic Information

Item	Details
Product Name	Pentafluorophenyl Acetate
CAS No.	19220-93-0
Molecular Formula	C8H3F5O2
Molecular Weight	226.10 g/mol
Synonyms	Acetic Acid Pentafluorophenyl Ester; PFP-Acetate; Pentafluorophenyl Ethanoate; 2,3,4,5,6-Pentafluorophenyl Acetate; Perfluorophenyl Acetate; PFP-OAc; NSC 518841; Pentafluorophenol Acetate
EINECS	Contact for details

Quality Control

Our Pentafluorophenyl Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide full traceability and a Certificate of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for use as a pharmaceutical intermediate, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.