Description

4-tert-Butylbenzyl Bromide is a versatile and highly reactive organic bromide intermediate, essential for advanced chemical synthesis. Its value lies in the strategic positioning of the tert-butyl group, which provides significant steric and electronic influence, making it a critical building block for creating complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring a bulky, lipophilic aromatic moiety.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators where the tert-butylbenzyl group enhances biological activity and stability.
• Ligand and Catalyst Preparation: Serves as a precursor for phosphine and N-heterocyclic carbene (NHC) ligands used in transition metal catalysis, including cross-coupling reactions.
• Material Science Monomer: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials to introduce specific steric and solubility properties.
• Chemical Research & Development: A valuable reagent for introducing the 4-tert-butylbenzyl protecting group or for further functionalization via nucleophilic substitution or metal-halogen exchange reactions.
• Fine Chemical Production: Intermediate in the manufacture of dyes, pigments, and flavor & fragrance compounds requiring specific aromatic substitution patterns.

Basic Information

Product Name	4-tert-Butylbenzyl Bromide
CAS No.	18880-00-7
Molecular Formula	C11H15Br
Molecular Weight	227.14 g/mol
Synonyms	1-(Bromomethyl)-4-tert-butylbenzene; p-tert-Butylbenzyl Bromide; (4-(tert-Butyl)phenyl)methyl Bromide; α-Bromo-4-tert-butyltoluene; 4-tert-Butyl-α-bromotoluene; 4-(tert-Butyl)benzyl Bromide; 4-tert-Butylbenzylbromide; 4-tert-Butyl-benzylbromid
EINECS	242-638-6

Quality Control

Our 4-tert-Butylbenzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for review and provided with every shipment to guarantee traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its reactivity, it should be stored under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.