Description

Chloromethyl Pivalate is a versatile organic ester compound, widely recognized as a key alkylating agent and a valuable building block in advanced organic synthesis. Its primary commercial value lies in its ability to introduce the pivaloyloxymethyl (POM) protecting group, which is crucial for enhancing the stability and bioavailability of active pharmaceutical ingredients. This makes it an essential raw material for research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Primarily used for the synthesis of prodrugs via the pivaloyloxymethyl (POM) protecting group strategy to improve drug solubility and membrane permeability.
• Agrochemical Synthesis: Serves as a key reagent in the production of advanced pesticides and herbicides, where it acts as an alkylating agent.
• Organic Synthesis Building Block: Employed in laboratory-scale and industrial-scale organic reactions for the introduction of the chloromethyl moiety in complex molecule construction.
• Polymer Chemistry: Used in the modification of polymers and in the synthesis of specialized monomers for functional materials.
• Chemical Research & Development: A critical reagent for medicinal chemistry and process chemistry research in developing new chemical entities.

Basic Information

Product Name	Chloromethyl Pivalate
CAS No.	18797-19-8
Molecular Formula	C6H11ClO2
Molecular Weight	150.60 g/mol
Synonyms	Pivaloyloxymethyl Chloride; Chloromethyl 2,2-Dimethylpropanoate; 2,2-Dimethylpropanoic Acid Chloromethyl Ester; POM-Chloride; Trimethylacetic Acid Chloromethyl Ester; Neopentanoic Acid Chloromethyl Ester; Chloromethyl Pivaloate; NSC 401071
EINECS	242-579-8

Quality Control

Our Chloromethyl Pivalate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its sensitivity to light and moisture, containers should be kept sealed under an inert atmosphere when not in use to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Purity (GC Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.