Description

2-(3,3-Dimethylindolin-2-Yl)Malonic Acid Diethyl Ester CAS NO 18781-64-1 is a high-purity, synthetically valuable indoline derivative and malonic ester building block. This compound is critical for advanced organic synthesis, serving as a versatile precursor for constructing complex heterocyclic frameworks. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those containing indoline or spirocyclic motifs.
• Agrochemical Synthesis: Used as a precursor for developing novel herbicides, fungicides, and insecticides with specific biological activity.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, dyes, and functional organic materials.
• Academic & Industrial R&D: Serves as a crucial starting material for methodological studies in organic chemistry and new reaction development.
• Spirocyclic Compound Synthesis: Facilitates the construction of spirooxindoles and related privileged structures important in medicinal chemistry.

Basic Information

Item	Details
Product Name	2-(3,3-Dimethylindolin-2-Yl)Malonic Acid Diethyl Ester
CAS No.	18781-64-1
Molecular Formula	C₁₇H₂₃NO₄
Molecular Weight	305.37 g/mol
Synonyms	Diethyl 2-(3,3-dimethyl-2,3-dihydro-1H-indol-2-yl)malonate; 2-(3,3-Dimethyl-2,3-dihydro-1H-indol-2-yl)malonic Acid Diethyl Ester; 2-(3,3-Dimethylindolin-2-yl)malonic Acid Diethyl Ester; Ethyl 2-(3,3-dimethyl-2,3-dihydro-1H-indol-2-yl)malonate; 18781-64-1; Malonic acid, 2-(3,3-dimethyl-2,3-dihydro-1H-indol-2-yl)-, diethyl ester
EINECS	Contact for details

Quality Control

Our 2-(3,3-Dimethylindolin-2-Yl)Malonic Acid Diethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and excessive heat. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.