Description

(1R,5S,6R)-Rel-8-Methyl-8-Azabicyclo-[3.2.1]Octan-6-Ol CAS NO 18700-23-7 is a high-purity, stereochemically defined tropane alkaloid derivative, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in its rigid, three-dimensional bicyclic structure, which is essential for imparting specific biological activity and stereochemical control in final target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for neurological and receptor-targeting therapies.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug candidates, especially those targeting the central nervous system.
• Asymmetric Synthesis: Utilized as a sophisticated ligand or scaffold in catalytic asymmetric reactions to induce high enantioselectivity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore and optimize pharmacophores for new therapeutic agents.
• Neurological Research: Serves as a reference standard or starting material for compounds interacting with muscarinic or nicotinic acetylcholine receptors.
• Fine Chemical Production: Used in the multi-step synthesis of high-value specialty chemicals and advanced materials requiring precise stereochemistry.
• Academic Research: A valuable compound for methodological development in organic chemistry and for teaching advanced concepts in stereochemistry.

Basic Information

Product Name	(1R,5S,6R)-Rel-8-Methyl-8-Azabicyclo-[3.2.1]Octan-6-Ol
CAS No.	18700-23-7
Molecular Formula	C8H15NO
Molecular Weight	141.21 g/mol
Synonyms	8-Methyl-8-azabicyclo[3.2.1]octan-6-ol, (1R,5S,6R)-rel-; Tropan-6-ol, 8-methyl-, (1R,5S,6R)-rel-; 6-Hydroxy-8-methyl-8-azabicyclo[3.2.1]octane; rel-(1R,5S,6R)-8-Methyl-8-azabicyclo[3.2.1]octan-6-ol; Nortropine; Pseudotropine; ψ-Tropine; 3α-Hydroxytropane
EINECS	Contact for details

Quality Control

Our (1R,5S,6R)-Rel-8-Methyl-8-Azabicyclo-[3.2.1]Octan-6-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.