Description

(-)-Kaura-15-Ene-18-Oic Acid is a high-purity, chiral diterpenoid carboxylic acid characterized by its specific stereochemistry and kaurane skeleton. This compound serves as a critical chiral building block and advanced intermediate in the synthesis of complex natural products and novel pharmaceutical agents. It is primarily sought by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of bioactive diterpenoids.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, particularly in oncology and anti-inflammatory therapeutic areas.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and the design of new chemical entities based on the kaurane diterpenoid structure.
• Natural Product Synthesis: Serves as a crucial intermediate in the total or semi-synthesis of complex natural products belonging to the kaurane and related diterpenoid families.
• Process Chemistry: Employed in the development and scale-up of synthetic routes for active pharmaceutical ingredients (APIs) requiring this specific stereochemical configuration.
• Reference Standard: Used as an analytical standard in quality control laboratories for the identification and quantification of related compounds.

Basic Information

Product Name	(-)-Kaura-15-Ene-18-Oic Acid
CAS No.	18671-78-8
Molecular Formula	C₂₀H₃₀O₂
Molecular Weight	302.45 g/mol
Synonyms	(-)-Kaur-15-en-18-oic Acid; (4aS,5R,8aS)-5,8a-Dimethyl-3,4,4a,5,6,7,8,8a-octahydro-2H-naphthalene-1-carboxylic Acid; Kaur-15-en-18-oic Acid, (-)-; ent-Kaur-15-en-18-oic Acid; Kaur-15-ene-18-carboxylic Acid; Kaur-15-en-18-oate
EINECS	Contact for details

Quality Control

Our (-)-Kaura-15-Ene-18-Oic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and pharmaceutical development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.